SCIENTIFIC REVIEW · BIOCHEMISTRY · NUTRACEUTICAL SCIENCE
TELOLAB™: Biological Efficacy
of a MultiMechanism
Geroprotective Extract
Antioxidant, Anti-Inflammatory, Telomere Extension, and Selective Anti-Cancer Activity in Validated Laboratory Models
PRIMARY INSTITUTION
Kasetsart University
AFFILIATED INSTITUTION
Maejo University-Phrae Campus
DEPARTMENT
Biochemistry
EXTRACT CLASS
Geroprotective Nutraceutical
ABSTRACT
TELOLAB™ is a proprietary multi-component nutraceutical extract comprising 9 medicinal plant botanicals and 1 algal species. It has undergone systematic laboratory evaluation across four primary biological dimensions. Key findings include: (1) Reduction of reactive oxygen species (ROS) by 10.55% in RAW 264.7 macrophage cells (DCFH-DA assay, p<0.01) with dose-dependent yeast survival under H₂O₂ oxidative challenge; (2) Selective cytokine modulation: IL-6 suppression of 73.65%, TNF-α reduction of 40.17%, and IL-10 upregulation of 32.42% (ELISA, LPS-stimulated model); (3) Telomere length extension in HeLa cells of +58.5% at 125 µg/mL (qRT-PCR, ΔΔCq method, p<0.001); (4) Selective cytotoxicity against MCF-7 breast cancer cells at IC₅₀ = 87.78 µg/mLwith normal cell viability maintained above 80% at equivalent concentrations. These results establish TELOLAB™ as a synergistic, multi-target geroprotective agent with strong laboratory evidence supporting its biological validity.
Keywords: TELOLAB™ · geroprotective nutraceutical · antioxidant · anti-inflammatory · telomere extension · selective cytotoxicity · Nrf2 pathway · Sirtuin activation · multi-mechanism synergy
73.65%
IL-6 Reduction
(Anti-inflammatory)
+58.5%
Telomere Length
Extension in HeLa Cells
87.75
IC₅₀ µg/mL
MCF-7 Breast Cancer
>80%
Normal Cell
Viability Maintained
FOUR-MECHANISM BIOLOGICAL PROFILE
How TELOLAB™ Acts on the Biology of Aging
TELOLAB™ interrupts the aging cascade at four molecularly distinct and interconnected targets —
a multi-mechanism architecture that no single-compound supplement can replicate
Antioxidant ActivityNRF2 / ROS PATHWAYTELOLAB™ activates the Nrf2 transcription factor — the master cellular antioxidant switch — inducing SOD, CAT, HO-1, and NQO1 enzymes. Active contributors include Astragalus membranaceus, Vitis sp., astaxanthin from Haematococcus pluvialis, and additional proprietary co-actives within the matrix.10.55%ROS reduction in RAW 264.7 macrophage cells at 500 µg/mL (DCFH-DA, p<0.01)Dose-dep.S. cerevisiae survival under H₂O₂ oxidative stress (in vivo model)
Telomere Extension
MULTITARGET SYNERGY
Why Four Mechanisms Are Stronger Than One
The biological aging cascade operates as an interconnected loop — not a linear progression. TELOLAB™ is uniquely designed to interrupt this loop at multiple points simultaneously, creating a virtuous cycle that counters each hallmark of cellular aging.Critically, the anti-inflammatory and antioxidant effects directly amplify the telomere extension effect — and all three together reduce the oncogenic signaling environment that promotes cancer growth.Type your paragraph hereType your paragraph here
ANTI-INFLAMMATORY — IL-6 SUPPRESSION
73.65%
IL-6 is both a key inflammatory cytokine and a direct activator of STAT3, which drives cancer proliferation and telomere shortening simultaneously. TELOLAB™'s IL-6 suppression therefore delivers triple-pathway benefit in a single mechanism.
ELISA · LPS-stimulated RAW 264.7 · n=3 independent experiments · p<0.001
TELOMERE EXTENSION — HELA CELLS
58.5%
The largest single-dose telomere extension result in this formula class, achieved at 125 µg/mL via dual mechanism (direct TERT activation + oxidative DNA protection). The dose-dependent relationship confirms specificity of effect.
qRT-PCR (ΔΔCq method) · 24h incubation · Gold-standard telomere measurement · p<0.001
PROPRIETARY FORMULA
Multi-Botanical Synergy Matrix
TELOLAB™ is a proprietary concert of medicinal plant extracts and a select algal species — engineered so that each bioactive compound reinforces the others. The formula's power is not in any single ingredient, but in the convergence of their mechanisms on the same anti-aging cascade.
The complete botanical index is held under trade-secret protection. What we share publicly is the architecture — the four pathway pillars, representative signature actives, and the quantified synergistic outcomes validated at Kasetsart University and Maejo University-Phrae Campus.
PILLAR · 01
Antioxidant Defence
Multi-compartment ROS quenching — mitochondrial, membrane, and nuclear — activating the Nrf2 master antioxidant switch and its downstream enzymes (SOD, CAT, HO-1, NQO1).
NRF2 AXIS · −10.55% ROS
PILLAR · 02
Anti-Inflammatory Modulation
NF-κB pathway suppression and balanced cytokine regulation — reducing pro-inflammatory signals while simultaneously up-regulating anti-inflammatory IL-10.
NF-ΚB ↓ · IL-6 −73.65%
PILLAR · 03
Telomere & Telomerase
Direct TERT mRNA up-regulation combined with oxidative DNA protection — a dual mechanism producing the largest single-dose telomere extension yet observed in this formula class.
TERT ↑ · TELOMERE +58.5%
PILLAR · 04
Selective Anti-Cancer Activity
STAT3 dephosphorylation, apoptosis induction, and Ras oncogene inhibition — achieving cytotoxicity against cancer cell lines while preserving >80% normal-cell viability.
MCF-7 IC₅₀ · 87.78 ΜG/ML
SIGNATURE ACTIVES · PUBLICLY DISCLOSED
· Astragalus membranaceus — traditionally documented telomerase support via cycloastragenol; anchor of the telomere pillar.
· Haematococcus pluvialis (algae) — source of astaxanthin, the highest-potency mitochondrial antioxidant in the food spectrum.
· Vitis vinifera — resveratrol & OPC proanthocyanidins; SIRT1 longevity-gene activation.
· Curcuma longa — curcumin; comprehensive NF-κB / COX-2 / STAT3 pathway modulation.Type your paragraph here
ADDITIONAL PROPRIETARY EXTRACTS
+ Six additional botanical extracts
Selected for anti-inflammatory cascade completion, neuroprotection, telomerase modulation, and selective anti-cancer activity. Identities retained under trade-secret.
The complete 10-component formulation, extraction ratios, and co-active pairings constitute TELOLAB™ proprietary intellectual property. All results published in this document were validated on the full, unaltered formula — no single component is independently marketed.
Why Synergy Matters
No single plant — not even the most studied longevity compound — simultaneously elevates telomerase activity, suppresses NF-κB, and induces selective cancer-cell apoptosis at the same dose window. TELOLAB™'s multi-botanical matrix resolves this limitation by design: each compound contributes a distinct mechanism, yet all converge on four overlapping molecular pathways. The quantified outcomes below are measured on the composite formula — not additive predictions.
4
CONVERGENT
PATHWAYS
10
BOTANICAL
COMPONENTS
8
VALIDATED
ASSAY ENDPOINTS
2
INDEPENDENT
UNIVERSITIES
LABORATORY-VERIFIED DATA
Quantified Biological Results
All results from independent, replicated laboratory assays using standardised validated methodologies
10.55%
ROS Reduction in RAW 264.7 Macrophage Cells
DCFH-DA Assay · 500 µg/mL · p<0.01
73.65%
IL-6 Suppression in LPS-Stimulated Cells
ELISA · n=3 independent experiments · p<0.001
40.17%
TNF-α Reduction at Equivalent Concentration
ELISA · LPS-stimulated model · p<0.01
+32.42%
IL-10 Upregulation — Anti-inflammatory Balance
ELISA · Demonstrates immunomodulation, not immunosuppression
+58.5%
Telomere Length Extension in HeLa Cells
qRT-PCR (ΔΔCq) · 125 µg/mL · 24h · p<0.001
87.78
IC₅₀ µg/mL — MCF-7 Breast Cancer (MTT, 72h)
Comparable to purified B. monnieri (72–75 µg/mL in literature)
+7.47%
Macrophage Phagocytic Activity Enhancement
500 µg/mL · Innate immune activation · p<0.05
>80%
Normal Cell Viability at Anti-Cancer Concentrations
RAW 264.7 viability — confirms selective cytotoxicity profile
BIOCHEMICAL ARCHITECTURE
Molecular Pathway Integration
TELOLAB™'s four mechanisms are not independent
they share overlapping molecular targets, creating a self-reinforcing anti-aging cascade
ACADEMIC & SCIENTIFIC VALIDATION
Laboratory Evaluation Infrastructure
TELOLAB™'s biological efficacy data is grounded in validated laboratory methodologies
consistent with international standards in nutraceutical and pharmacological research
🎓 Kasetsart University
Department of Biochemistry
· Primary Research Institution
Primary evaluation laboratory for TELOLAB™ biological efficacy studies. Kasetsart University
is one of Thailand's premier research institutions with internationally recognized biochemistry and pharmacological science programs.
PRIMARY RESEARCH INSTITUTION
🔬 Maejo University
Department of Biochemistry
· Affiliated Research Site
Affiliated research site contributing validated laboratory data. Maejo University's agricultural and life science research infrastructure provides validated supplementary analytical capacity for complex botanical formulations.
AFFILIATED RESEARCH INSTITUTION
📊 Validated Assay Methodology
Gold-Standard Laboratory Protocols
Primary evaluation laboratory for TELOLAB™ biological efficacy studies. Kasetsart University
is one of Thailand's premier research institutions with internationally recognized biochemistry and pharmacological science programs.
PRIMARY RESEARCH INSTITUTION
BIOLOGICAL ASSAY METHOD CELL / MODEL SYSTEM KEY RESULT STATISTICAL EVIDENCE
DIMENSION SIGNIFICANC LEVEL
Antioxidant (ROS)
DCFH-DA
Fluorescence
RAW 264.7 Macrophage
−10.55% ROS
p < 0.01
In vitro + in vivo
Anti-inflammatory (IL-6)
Sandwich ELISA
LPS-stimulated RAW 264.7
−73.65% IL-6
p < 0.001
In vitro
Anti-inflammatory (TNF-α)
Sandwich ELISA
LPS-stimulated RAW 264.7
−40.17% TNF-α
p < 0.01
In vitro
Immunomodulation (IL-10)
Sandwich ELISA
LPS-stimulated RAW 264.7
+32.42% IL-10
p < 0.05
In vitro
Telomere Extension
qRT-PCR (ΔΔCq)
HeLa Cells (cervical)
+58.5% at 125 µg/mL
p < 0.001
In vitro
Anti-Cancer (MCF-7)
MTT Cytotoxicity
MCF-7 Breast Cancer
IC₅₀ = 87.78 µg/mL
p < 0.05
In vitro
Normal Cell Safety
MTT Viability
RAW 264.7 Normal
>80% viability
p < 0.05
In vitro
Innate Immunity
Phagocytosis Assay
Macrophage Phagocytic Activity
+7.47% at 500 µg/mL
p < 0.05
In vitro
PROPRIETARY TRADEMARK EXTRACT
The TELOLAB™ name, formulation composition, and associated biological efficacy claims are subject to trademark protection. Unauthorized reproduction of the name or formula is prohibited.
TRADEMARK & INTELLECTUAL PROPERTY
TELOLAB™ — Protected Proprietary Extract
TELOLAB™ represents a novel, proprietary botanical combination with a specific, validated biological profile. The trademark protects both the name and the associated composition and claims — establishing exclusive commercial rights to the TELOLAB™ geroprotective extract brand.This website (www.telolab.info) serves as the official scientific reference for TELOLAB™, providing evidence-based documentation of the extract's biological mechanisms, laboratory-validated efficacy data, and compositional profile for regulatory, licensing, and academic purposes.
TRADEMARK NAME PROTECTION
The designation "TELOLAB™" is a registered trademark. All use of the name in commercial or formulation contexts requires explicit licensing authorization.
FORMULA COMPOSITION REFERENCE
The 10-component botanical profile described herein constitutes the TELOLAB™ proprietary formulation. Independent replication of this specific combination without authorization is a trademark infringement.
BIOLOGICAL CLAIMS DOCUMENTATION
All biological efficacy claims associated with TELOLAB™ are documented on this reference site and supported by laboratory data from Kasetsart University and Maejo University-Phrae Campus.
LICENSING & FORMULATION INQUIRY
For licensing of the TELOLAB™ trademark for use in nutraceutical formulations, supplement products, or clinical research, contact our licensing team via the inquiry form below.
SCIENTIFIC REFERENCES
Literature & Research Citations
All biological efficacy data for TELOLAB™ is supported by peer-reviewed scientific
literature and direct laboratory evaluation reports. Key references below.
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Disclaimer: The biological efficacy data presented on this website is derived from in vitro laboratory evaluations conducted at Kasetsart University and Maejo University-Phrae Campus. These findings represent laboratory evidence and should not be interpreted as clinical claims for the prevention, treatment, or cure of any disease in humans. In vivo animal studies and human clinical trials are required for full regulatory substantiation of health claims. This website serves as a scientific reference for trademark documentation purposes.
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TELOLAB™ is available for licensing to qualified nutraceutical manufacturers, supplement brands, and clinical research
organizations seeking a scientifically validated geroprotective extract with documented biological efficacy.
EMAIL : telolab.info@gmail.com